Women in rural areas are less likely to have access to health care and more likely to have poorer health outcomes. The WHO has a gender-based approach, which addresses the specific health vulnerabilities and risks of rural women and girls that are addressed in health service delivery such as Covid-19 vaccination. Globally, Covid-19 has caused different health, social and economic outcomes. This led to the manufacturing of vaccines to manage the pandemic and has been a success story. The true measure of success depends on the rates of vaccine uptake globally and locally and among the marginalised populations. Therefore, this study looked at Covid 19 vaccine uptake among rural South women aged 15 and above. Data used were from the 2022 South African General Household Survey, a nationally representative survey. Descriptive statistics and multivariable logistic regression analysis were used to describe the characteristics of the sample and to identify factors associated with Covid-19 vaccine uptake amongst women who were 15 years and above in rural South Africa. Of the 7961 female respondents, 27.98% (2432) were between 15 and 24 years followed by those who were 45 years and older (26.53%, n=2537). The number of respondents who took the Covid-19 vaccine were almost the same as those who never had (48.5% vs. 48.6%). A higher percentage of those who were on a medical aid scheme took the Covid-19 vaccine than those who were not on the scheme (74.8% vs. 48.4%; p<0.001). Women with more than a grade 12 education were more likely to have taken the Covid-19 vaccine compared to those with no education. Those who did not have a cell phone were less likely to have taken the vaccine compared to those who had a cell phone. Other factors that were associated with Covid-19 vaccine uptake were-marital status, Covid-19 diagnosis, having a medical aid/insurance, diagnosis of hypertension by a physician, ethnicity/race, self-rated health, and age. Understanding factors affecting vaccine uptake allows for more targeted, equitable and effective vaccination campaigns. The study showed the different factors that affect Covid-19 uptake amongst rural women in South Africa.