This article examines the role of faith-based organizations (FBOs) in delivering HIV/AIDS services to the population of Zambia. It outlines the causes of HIV transmission, the development of community initiatives to provide services and education programs to underserved families and orphans affected by the disease, and activities of multinational organizations as they partner with FBOs to strengthen education programs, provide for orphans, deliver services, and develop community relationships. The paper suggests strategies for strengthening partnerships, identifies problems that affect the implementation of strategies, and makes recommendations for developing sustainable community relationships.