The COVID-19 Vaccine Survey (CVACS) is a South African national panel study of individuals initially unvaccinated against COVID-19. The purpose of CVACS is to collect high quality, timely, and relevant information on facilitators and barriers to COVID-19 vaccine uptake - including vaccine hesitancy and access constraints - to contribute to the development of data-driven campaigns and programmes to increase COVID-19 vaccination uptake in South Africa. Multiple outcomes are measured by CVACS, such as vaccination knowledge, attitudes, and beliefs (including specific concerns); vaccination intentions (plans to get vaccinated), vaccine access constraints, and information seeking. To ensure that the most policy-relevant information is collected, the questionnaires were co-created with academics, policymakers, and members of civil society organizations involved in the COVID-19 response and vaccination roll-out. The purpose of CVACS is to collect high quality, timely, and relevant information on facilitators and barriers to COVID-19 vaccine uptake to contribute to the development of data-driven campaigns and programmes to increase COVID-19 vaccination uptake in South Africa.