Research funding agencies and journal publishers are increasingly expecting academics to make the data and code underlying their research widely available to ensure transparent, replicable, and reproducible research. Open scientific processes such as open data practices can improve science communication and improve the quality of published research. The datasets in this collection are deposited by South Africa-based researchers and research projects that are committed to or have funding agreements to share their data as evidence underlying their research. The data is available for re-analysis or secondary analysis.